Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HRH1 | P35367 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.50 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306585 | 1.00 | HTR2A (0.59) | HTR2AHRH1TDP1GABBR2GABBR1 | |
| SCHEMBL8754723 | 0.87 | HTR2A (0.70) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL22699690 | 0.84 | HTR2A (0.55) | HTR2AHRH1TDP1GABBR2GABBR1 | |
| SCHEMBL11736005 | 0.83 | HTR2A (0.50) | HTR2AHRH1TDP1GABBR2GABBR1 | |
| SCHEMBL21739938 | 0.81 | HTR2A (0.61) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL21739939 | 0.81 | HTR2A (0.61) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL3428926 | 0.81 | HTR2A (0.61) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL1539105 | 0.79 | TAAR1 (0.65) | HTR2AHRH1GABBR2GABBR1TAAR1 | |
| SCHEMBL12712357 | 0.79 | HTR2A (0.59) | HTR2AHRH1TDP1SLC6A2SLC6A4 | |
| SCHEMBL9807100 | 0.79 | HTR2A (0.59) | HTR2AHRH1TDP1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0997474-A1 | Antithrombotic agents | PFIZER INC. (US) | 2000-05-03 | — | — | EP | disclosed |