Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 19/20 | 0.60 |
| ▸ | CCKAR | P32238 | 9/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | TSPO | P30536 | 1/20 | 0.47 |
| ▸ | GLP1R | P43220 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627846 | 0.86 | CCKBR (0.58) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL8630089 | 0.85 | CCKBR (0.56) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL9423149 | 0.80 | CCKBR (0.75) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7302916 | 0.79 | CCKBR (0.72) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7307910 | 0.78 | CCKBR (0.49) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL7307913 | 0.76 | CCKBR (0.43) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL7312521 | 0.75 | CCKBR (0.68) | CCKBR | |
| SCHEMBL7311045 | 0.75 | CCKBR (0.73) | CCKBRCCKAR | |
| SCHEMBL7312542 | 0.74 | CCKBR (0.74) | CCKBR | |
| SCHEMBL7304411 | 0.74 | CCKBR (0.70) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5798353-A | Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-08-25 | — | — | US | disclosed |
| US-5719143-A | Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-02-17 | — | — | US | disclosed |
| EP-0667344-A1 | 3-acylamino-5-(polysubstituted phenyl)-1,4-benzodiazepin-2-ones useful as CCK-receptor agonists | SANOFI (FR) | 1995-08-16 | — | — | EP | disclosed |