Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 16/20 | 0.72 |
| ▸ | CCKAR | P32238 | 12/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.72 |
| ▸ | TSPO | P30536 | 1/20 | 0.72 |
| ▸ | GLP1R | P43220 | 1/20 | 0.72 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | PDE1A | P54750 | 2/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.49 |
| ▸ | PYGM | P11217 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310917 | 0.93 | CCKBR (0.72) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL27365740 | 0.91 | CCKBR (0.69) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7305691 | 0.90 | CCKBR (0.68) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL27365742 | 0.87 | CCKBR (0.65) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL4884074 | 0.84 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL8613468 | 0.84 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL29406251 | 0.84 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL6255769 | 0.84 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL148766 | 0.84 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL31616311 | 0.84 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5798353-A | Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-08-25 | — | — | US | disclosed |
| US-5719143-A | Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-02-17 | — | — | US | disclosed |
| EP-0667344-A1 | 3-acylamino-5-(polysubstituted phenyl)-1,4-benzodiazepin-2-ones useful as CCK-receptor agonists | SANOFI (FR) | 1995-08-16 | — | — | EP | disclosed |