Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316734 | 0.93 | KCNH2 (0.37) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7307496 | 0.91 | KCNH2 (0.36) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7304312 | 0.90 | KCNH2 (0.34) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7309774 | 0.90 | MEN1 (0.38) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7308973 | 0.88 | ITGB3 (0.38) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7308269 | 0.87 | KDM4E (0.36) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7310562 | 0.87 | ITGB3 (0.37) | KCNH2ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL7314498 | 0.86 | ITGB3 (0.37) | ITGB3ITGA2BKDM4EMEN1KMT2A | |
| SCHEMBL7305713 | 0.86 | ITGB3 (0.37) | ITGB3ITGA2BKDM4EMEN1KMT2A | |
| SCHEMBL8858193 | 0.85 | KDM4E (0.36) | KCNH2ITGB3ITGA2BKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |