Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP3 | P08254 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 11/20 | 0.45 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304996 | 0.88 | MMP1 (0.57) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7313624 | 0.85 | MMP1 (0.41) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7349344 | 0.85 | MMP1 (0.61) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7299039 | 0.85 | MMP1 (0.46) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7311787 | 0.81 | MMP1 (0.56) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7301052 | 0.80 | MMP1 (0.54) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL8521085 | 0.79 | MMP1 (0.53) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7311728 | 0.78 | MMP1 (0.50) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7307395 | 0.78 | MMP1 (0.59) | MMP1MMP3MMP13MMP2MMP9 | |
| SCHEMBL7303375 | 0.78 | MMP1 (0.59) | MMP1MMP3MMP13MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1177821-C | Matrix metalloprotease inhibitors | - | 2004-12-01 | — | — | CN | disclosed |
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |