Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.41 |
| ▸ | MMP9 | P14780 | 10/20 | 0.41 |
| ▸ | MMP13 | P45452 | 9/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 7/20 | 0.40 |
| ▸ | MMP3 | P08254 | 5/20 | 0.40 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 3/20 | 0.38 |
| ▸ | MMP10 | P09238 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308944 | 0.92 | MMP1 (0.51) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7301752 | 0.91 | MMP1 (0.52) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7302735 | 0.88 | MMP1 (0.54) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7307266 | 0.85 | MMP1 (0.49) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7349344 | 0.82 | MMP1 (0.61) | MMP1MMP9MMP13MMP14MMP3 | |
| SCHEMBL7299039 | 0.82 | MMP1 (0.46) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7301052 | 0.81 | MMP1 (0.54) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7299271 | 0.79 | MMP1 (0.66) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7302817 | 0.79 | MMP1 (0.67) | MMP1MMP9MMP13ADAM17MMP14 | |
| SCHEMBL7311787 | 0.78 | MMP1 (0.56) | MMP1MMP9MMP13ADAM17MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |