Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.61 |
| ▸ | MMP9 | P14780 | 11/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.61 |
| ▸ | MMP1 | P03956 | 8/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092889 | 0.81 | MMP13 (0.67) | MMP13MMP9ADAM17MMP1NR3C1 | |
| SCHEMBL7316136 | 0.80 | MMP13 (0.79) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL7313797 | 0.80 | MMP13 (0.72) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL7316882 | 0.78 | MMP13 (0.63) | MMP13MMP9ADAM17MMP1NR3C1 | |
| SCHEMBL7310743 | 0.78 | MMP13 (0.94) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL7317150 | 0.78 | MMP13 (0.78) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL7318672 | 0.78 | MMP13 (0.71) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL7323169 | 0.77 | MMP13 (0.74) | MMP13MMP9ADAM17MMP1KEAP1 | |
| SCHEMBL7325500 | 0.75 | MMP13 (0.87) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL6813864 | 0.73 | MMP13 (0.68) | MMP13MMP9ADAM17MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |