Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.63 |
| ▸ | MMP9 | P14780 | 8/20 | 0.63 |
| ▸ | MMP1 | P03956 | 7/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.62 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317150 | 0.90 | MMP13 (0.78) | MMP13MMP9MMP1ADAM17TDP1 | |
| SCHEMBL6814341 | 0.90 | MMP13 (0.65) | MMP13MMP9MMP1ADAM17TAS2R14 | |
| SCHEMBL5092889 | 0.89 | MMP13 (0.67) | MMP13MMP9MMP1ADAM17NR3C1 | |
| SCHEMBL7322655 | 0.87 | MMP13 (0.83) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7325555 | 0.85 | MMP13 (0.83) | MMP13MMP9MMP1ADAM17TDP1 | |
| SCHEMBL7324943 | 0.83 | MMP13 (0.84) | MMP13MMP9MMP1ADAM17KMT2A | |
| SCHEMBL6811198 | 0.81 | MMP13 (0.65) | MMP13MMP9MMP1ADAM17TDP1 | |
| SCHEMBL7316120 | 0.80 | MMP13 (0.72) | MMP13MMP9MMP1ADAM17TAS2R14 | |
| SCHEMBL6813864 | 0.79 | MMP13 (0.68) | MMP13MMP9MMP1ADAM17TDP1 | |
| SCHEMBL7323146 | 0.78 | MMP13 (0.73) | MMP13MMP9MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |