Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LOX | P28300 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081804 | 0.90 | MAPK8 (0.63) | MAPK8HPGDKMT2ALOXLOXL2 | |
| SCHEMBL7310026 | 0.88 | MAPK8 (1.00) | MAPK8ALDH1A1 | |
| SCHEMBL4098042 | 0.88 | MAPK8 (0.60) | MAPK8HPGDKMT2ALOXLOXL2 | |
| SCHEMBL7319190 | 0.87 | MAPK8 (0.78) | MAPK8HPGDKMT2AALDH1A1 | |
| SCHEMBL7313604 | 0.86 | MAPK8 (0.67) | MAPK8HPGDKMT2AALDH1A1 | |
| SCHEMBL7371941 | 0.85 | MAPK8 (0.65) | MAPK8HPGDKMT2A | |
| SCHEMBL8756555 | 0.82 | MAPK8 (0.78) | MAPK8HPGDKMT2AALDH1A1 | |
| SCHEMBL5608707 | 0.81 | MAPK8 (0.52) | MAPK8 | |
| SCHEMBL6051217 | 0.81 | PTGER4 (0.61) | MAPK8KMT2A | |
| SCHEMBL7374630 | 0.80 | MAPK8 (0.58) | MAPK8HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |