Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14193488 | 0.90 | MAPK8 (0.82) | MAPK8 | |
| SCHEMBL7319190 | 0.88 | MAPK8 (0.78) | MAPK8ALDH1A1 | |
| SCHEMBL7307728 | 0.88 | MAPK8 (0.78) | MAPK8ALDH1A1 | |
| SCHEMBL8756555 | 0.88 | MAPK8 (0.78) | MAPK8ALDH1A1 | |
| SCHEMBL10073050 | 0.87 | MAPK8 (0.77) | MAPK8ALDH1A1 | |
| SCHEMBL2485262 | 0.86 | MAPK8 (0.75) | MAPK8 | |
| SCHEMBL7317640 | 0.86 | MAPK8 (0.75) | MAPK8 | |
| SCHEMBL7366565 | 0.85 | MAPK8 (0.73) | MAPK8ALDH1A1 | |
| SCHEMBL7168843 | 0.84 | MAPK8 (0.72) | MAPK8GAA | |
| SCHEMBL8568262 | 0.83 | ALDH1A1 (0.74) | MAPK8ALDH1A1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |