Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12632978 | 1.00 | KDM4E (0.50) | KDM4EHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL10857129 | 0.85 | — | — | |
| SCHEMBL6644034 | 0.81 | KDM4E (0.75) | KDM4EHTTSMN1; SMN2POLBMEN1 | |
| SCHEMBL3535515 | 0.79 | KDM4E (0.79) | KDM4EHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16822348 | 0.79 | KDM4E (0.79) | KDM4EHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20842216 | 0.78 | GNAI3 (0.43) | KDM4EHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL22375241 | 0.77 | KDM4E (0.47) | KDM4EHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL11133425 | 0.74 | GNAI3 (0.41) | KDM4EHTTSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL5646115 | 0.74 | GNAI3 (0.47) | KDM4EHTTGNAI3GNAO1GNAI1 | |
| SCHEMBL16015488 | 0.73 | ADRB1 (0.49) | KDM4EHTTSMN1; SMN2DPP7HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1069640-C | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2001-08-15 | — | — | CN | disclosed |
| US-5776937-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-07-07 | — | — | US | disclosed |
| CN-1132201-A | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 1996-10-02 | — | — | CN | disclosed |
| EP-0711770-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-15 | — | — | EP | disclosed |