Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984006 | 1.00 | MAP3K14 (0.33) | MAP3K14CRBN | |
| SCHEMBL10400960 | 0.72 | CRBN (0.36) | MAP3K14CRBN | |
| SCHEMBL5909391 | 0.71 | MAP3K14 (0.55) | MAP3K14CRBN | |
| SCHEMBL18545242 | 0.69 | MAP3K14 (0.33) | MAP3K14CRBN | |
| SCHEMBL455753 | 0.69 | — | — | |
| SCHEMBL3628793 | 0.69 | MAP3K14 (0.33) | MAP3K14CRBN | |
| SCHEMBL14139685 | 0.69 | — | — | |
| SCHEMBL25366289 | 0.69 | POLB (0.35) | MAP3K14CRBN | |
| SCHEMBL17432744 | 0.67 | BRD4 (0.41) | MAP3K14CRBN | |
| SCHEMBL7298906 | 0.67 | KDM4E (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454121-B1 | Azatetracyclic compounds | SEARLE & CO (US) | 1996-11-13 | — | — | EP | disclosed |
| US-5223613-A | Prepared from cyclopenta(c)pyrrole derivatives; drug intermediates; antiemetics, anixiolytics | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5140023-A | Serontonin antagonist; gastrointestinal and psychological disorders; analgesics; antidepressants | G. D. SEARLE & CO. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0454121-A2 | Azatetracyclic compounds | G.D. Searle & Co. (US) | 1991-10-30 | — | — | EP | disclosed |