SCHEMBL730788

SCHEMBL730788

O=C(OC(=O)C(Cl)(Cl)Cl)c1ccccc1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.53
TSHR P16473 2/20 0.53
HPGD P15428 7/20 0.50
HSD17B10 Q99714 5/20 0.50
ALOX15 P16050 1/20 0.50
TDP1 Q9NUW8 2/20 0.49
KDM4E B2RXH2 6/20 0.46
ALDH1A1 P00352 5/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
HMGB1 P09429 1/20 0.45
CA4 P22748 1/20 0.45
CA6 P23280 1/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.45
NAPRT Q6XQN6 1/20 0.45
CA14 Q9ULX7 1/20 0.45
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29525350 0.82 LMNA (0.68) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL3908136 0.82 LMNA (0.68) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL28213156 0.81 LMNA (0.58) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL1491974 0.76 HPGD (0.62) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL27757206 0.76 ESR1 (0.55) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL23795259 0.75 HPGD (0.60) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL9561863 0.75 LMNA (0.59) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL285141 0.75 LMNA (0.64) LMNATSHRHPGDHSD17B10ALOX15
SCHEMBL1742375 0.75 LMNA (0.52) LMNATSHRHSD17B10TDP1ALDH1A1
SCHEMBL10780992 0.75 HPGD (0.59) LMNATSHRHPGDHSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3266450-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF Abraxis BioScience, LLC (US) 2018-01-10 EP disclosed
CN-101579335-B The preparation of medicament and methods for making and using same thereof 阿布拉科斯生物科学有限公司 2016-08-03 CN disclosed
US-20160151325-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF ABRAXIS BIOSCIENCE LLC (US) 2016-06-02 US disclosed
US-20150111960-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF ABRAXIS BIOSCIENCE LLC (US) 2015-04-23 US disclosed
US-20150104521-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF ABRAXIS BIOSCIENCE, LLC (US) 2015-04-16 US disclosed
US-8853260-B2 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof ABRAXIS BIOSCIENCE, LLC (US) 2014-10-07 US disclosed
EP-1023050-B1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF ABRAXIS BIOSCIENCE LLC (US) 2013-09-25 EP disclosed
US-20120231082-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF DESAI NEIL P (US) 2012-09-13 US disclosed
US-8137684-B2 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof ABRAXIS BIOSCIENCE, LLC (US) 2012-03-20 US disclosed
EP-2272504-A2 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof Abraxis BioScience, LLC (US) 2011-01-12 EP disclosed
US-20070116761-A1 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof ABRAXIS BIOSCIENCE, INC. 2007-05-24 US disclosed
US-20070092563-A1 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof ABRAXIS BIOSCIENCE, INC. (US) 2007-04-26 US disclosed
US-20070093547-A1 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof ABRAXIS BIOSCIENCE, LLC 2007-04-26 US disclosed
US-20070087022-A1 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof ABRAXIS BIOSCIENCE, INC. (US) 2007-04-19 US disclosed
EP-1023050-A4 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF AMERICAN BIOSCIENCE INC (US) 2006-08-30 EP disclosed
CN-1515246-A New preparation of medicine, its preparation and application method �Ϻ���ͨ��ѧ 2004-07-28 CN disclosed
CN-1267214-A Novel preparation of medicament and preparation and application method thereof VIVORX PHARMACEUTICALS INC (US) 2000-09-20 CN disclosed
EP-1023050-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF Vivorx Pharmaceuticals, Inc. (US) 2000-08-02 EP disclosed
WO-1999000113-A9 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF VIVORX PHARMACEUTICALS INC (US) 1999-04-08 WO disclosed
WO-1999000113-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF VIVORX PHARMACEUTICALS, INC. (US) 1999-01-07 WO disclosed