Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 17/20 | 0.51 |
| ▸ | PYGL | P06737 | 16/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752638 | 1.00 | PYGM (0.51) | PYGMPYGLNR3C2KDM4E | |
| SCHEMBL5754356 | 1.00 | PYGM (0.51) | PYGMPYGLNR3C2KDM4E | |
| SCHEMBL6951169 | 0.92 | NR3C2 (0.43) | PYGMPYGLNR3C2KDM4E | |
| SCHEMBL6951538 | 0.91 | PYGM (0.51) | PYGMPYGLNR3C2 | |
| SCHEMBL9230837 | 0.90 | PYGM (0.51) | PYGMPYGLNR3C2 | |
| SCHEMBL6947787 | 0.89 | PYGM (0.55) | PYGMPYGLNR3C2 | |
| SCHEMBL6952771 | 0.85 | NR3C2 (0.42) | PYGMPYGLNR3C2 | |
| SCHEMBL8877848 | 0.83 | PYGL (0.39) | PYGMPYGL | |
| SCHEMBL5080218 | 0.82 | PYGL (0.38) | PYGMPYGLNR3C2KDM4E | |
| SCHEMBL5753848 | 0.81 | NR3C2 (0.38) | PYGMPYGLNR3C2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657430-B1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1999-06-02 | — | — | EP | claimed |
| EP-0657430-A1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1995-06-14 | — | — | EP | claimed |
| EP-0657430-B1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0657430-B1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0761651-A2 | Process for preparing optically active ortho-substituted 4-aryl-dihydropyridines | BAYER AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| EP-0657430-A1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0657430-A1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0657430-A1 | Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |