SCHEMBL7308001

SCHEMBL7308001

CCCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.55
AGTR2 P50052 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7309505 0.95 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL7313176 0.92
SCHEMBL7432496 0.92 AGTR1 (0.61) AGTR1AGTR2
SCHEMBL7300493 0.92 AGTR1 (0.59) AGTR1AGTR2
SCHEMBL7301911 0.91 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL7308657 0.91 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL7308473 0.91 PPARG (0.54)
SCHEMBL7299228 0.91 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL8563799 0.90 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL7878631 0.90 AGTR1 (0.49) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0503785-B1 1-Biphenylimidazole derivatives, their preparation and their therapeutic use SANKYO CO (JP) 2001-04-25 EP disclosed
US-5646171-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1997-07-08 US disclosed
US-5616599-A HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
EP-0503785-A1 1-Biphenylimidazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1992-09-16 EP disclosed