⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308001 | 0.92 | AGTR1 (0.55) | — | |
| SCHEMBL7300493 | 0.92 | AGTR1 (0.59) | — | |
| SCHEMBL7308473 | 0.92 | PPARG (0.54) | — | |
| SCHEMBL7308185 | 0.91 | AGTR1 (0.54) | — | |
| SCHEMBL7311709 | 0.90 | AGTR1 (0.54) | — | |
| SCHEMBL7308657 | 0.89 | AGTR1 (0.48) | — | |
| SCHEMBL7886496 | 0.89 | AGTR1 (0.44) | — | |
| SCHEMBL7307024 | 0.88 | AGTR1 (0.51) | — | |
| SCHEMBL7312098 | 0.87 | ACHE (0.51) | — | |
| SCHEMBL7309505 | 0.87 | AGTR1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| CN-1045770-C | Process for preparing 1-biphenylmethylimidazole derivatives | SANKYO CO (JP) | 1999-10-20 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0503785-A1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-09-16 | — | — | EP | disclosed |