Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.67 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415900 | 0.86 | KMT2A (0.67) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL13652529 | 0.83 | POLB (0.58) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL9585233 | 0.82 | MEN1 (0.70) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL11111056 | 0.82 | ALDH1A1 (0.80) | KMT2AMEN1LMNACYP1A2CYP2C19 | |
| Acetic Acid SCHEMBL28914909 | 0.81 | MAPT (0.54) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL4943368 | 0.81 | MEN1 (0.68) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL9661011 | 0.81 | MAPT (0.78) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL4943364 | 0.81 | MEN1 (0.68) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL9711829 | 0.81 | MEN1 (0.68) | KMT2AMEN1LMNACYP1A2ADRB2 | |
| SCHEMBL11438891 | 0.81 | NR1H4 (0.62) | KMT2AMEN1LMNAADRB2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040105-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019040105-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |
| CN-1069309-C | N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphtalene-2-carboxamide derivative, preparation and application of same | SANNOFFE SYNTHELABO (FR) | 2001-08-08 | — | — | CN | disclosed |
| EP-0666250-B1 | Derivatives of N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide having neuroprotective and anti-ischemic properties, their preparation and their use, in therapy | SYNTHELABO (FR) | 1998-02-11 | — | — | EP | disclosed |
| US-5663183-A | CEREBRAL DISORDERS | SYNTHELABO (FR) | 1997-09-02 | — | — | US | disclosed |
| US-5550162-A | TREATMENT AND PREVENTION OF CEREBRAL DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| EP-0666250-A1 | Derivatives of N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide having neuroprotective and anti-ischemic properties, their preparation and their use, in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |