Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.68 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943368 | 1.00 | MEN1 (0.68) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| Hydrochloric Acid SCHEMBL10604050 | 0.98 | MEN1 (0.67) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| SCHEMBL9585233 | 0.86 | MEN1 (0.70) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| SCHEMBL9661011 | 0.85 | MAPT (0.78) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| SCHEMBL9711829 | 0.85 | MEN1 (0.68) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| SCHEMBL10415900 | 0.84 | KMT2A (0.67) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| SCHEMBL10485622 | 0.82 | MEN1 (0.65) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| Practolol SCHEMBL39925 | 0.81 | ADRB2 (1.00) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| Practolol SCHEMBL39926 | 0.81 | ADRB2 (1.00) | MEN1KMT2ACYP1A2TSHRADRB2 | |
| SCHEMBL11857354 | 0.81 | ADRB2 (0.71) | MEN1KMT2ACYP1A2TSHRADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167318-A1 | Pharmaceutically active pyrrolidine derivatives | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2008-07-10 | — | — | US | disclosed |
| US-7211601-B2 | Pharmaceutically active pyrrolidine derivatives | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2007-05-01 | — | — | US | disclosed |
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | disclosed |
| EP-1268418-B1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-14 | — | — | EP | disclosed |
| US-7018988-B2 | Pharmaceutically active pyrrolidine derivatives as Bax inhibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-03-28 | — | — | US | disclosed |
| US-6962945-B2 | N-aryloxypropanolyl-N′-phenethyl-urea | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-11-08 | — | — | US | disclosed |
| US-20050215631-A1 | NOVEL N-ARYLOXYPROPANOLYL-N' - PHENETHYL - UREA | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-09-29 | — | — | US | disclosed |
| WO-2005063699-A1 | N-ARYLOXYPROPANOLYL-N’-PHENETHYL-UREA | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2005-07-14 | — | — | WO | disclosed |
| US-20030212012-A1 | Pharmaceutically active pyrrolidine derivatives | MERCK SERONO SA (CH) | 2003-11-13 | — | — | US | disclosed |
| US-20030171309-A1 | Pharmaceutically active pyrrolidine derivatives as bax inhibitors | MERCK SERONO SA (CH) | 2003-09-11 | — | — | US | disclosed |
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |
| EP-0117089-A1 | Beta-adrenergic antagonist compounds and derivatives of beta-adrenergic antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1984-08-29 | — | — | EP | disclosed |
| US-4388308-A | N6 -[(2-Hydroxypropyl)aryl]adenosines | G.D. SEARLE & CO. (US) | 1983-06-14 | — | — | US | disclosed |
| US-4020071-A | B-ADRENOLYTIC, ANTIARRHYTHMIA | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1977-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212012-A1 | Pharmaceutically active pyrrolidine derivatives | OXTR, CNR1, PRLHR | MEN1 4853/4885KMT2A 2950/4885CYP1A2 1142/4885 |
| US-20080167318-A1 | Pharmaceutically active pyrrolidine derivatives | OXTR, PRLHR, NR0B1 | MEN1 4860/4885KMT2A 3594/4885CYP1A2 1533/4885 |
| US-20050215631-A1 | NOVEL N-ARYLOXYPROPANOLYL-N' - PHENETHYL - UREA | NPY4R, GPR119, MC4R | MEN1 3594/4885KMT2A 1285/4885CYP1A2 1033/4885 |
| US-20030171309-A1 | Pharmaceutically active pyrrolidine derivatives as bax inhibitors | SUCNR1, PYCR1, GLS | MEN1 4751/4885KMT2A 2727/4885CYP1A2 1243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.