Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1466280 | 0.89 | ALDH1A1 (0.50) | GAANPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL29896410 | 0.89 | ALDH1A1 (0.50) | GAANPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7306658 | 0.87 | PDPK1 (0.42) | GAASMN1; SMN2RAB9AALDH1A1MEN1 | |
| SCHEMBL7308745 | 0.87 | AR (0.41) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL20150583 | 0.85 | MEN1 (0.57) | GAANPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11088181 | 0.84 | GAA (0.40) | GAANPSR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7313954 | 0.84 | PSMB5 (0.41) | GAASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL1466285 | 0.84 | PDGFRB (0.51) | GAANPSR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10807449 | 0.84 | DYRK1A (0.46) | GAANPSR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5773359 | 0.84 | HTT (0.53) | GAANPSR1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312870-A | TRANQUILIZERS, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1982-01-26 | — | — | US | claimed |
| EP-0022078-A1 | Pyrazolo-quinolines, processes for their production, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1981-01-07 | — | — | EP | claimed |
| US-4758427-A | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0214092-A1 | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone | CIBA-GEIGY AG (CH) | 1987-03-11 | — | — | EP | disclosed |
| EP-0022078-B1 | PYRAZOLO-QUINOLINES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1984-07-25 | — | — | EP | disclosed |
| US-4312870-A | TRANQUILIZERS, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1982-01-26 | — | — | US | disclosed |
| EP-0022078-A1 | Pyrazolo-quinolines, processes for their production, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1981-01-07 | — | — | EP | disclosed |