SCHEMBL7308564

SCHEMBL7308564

CCCCc1nc(C(=O)C(C)C)c(C#N)n1Cc1ccc(-c2ccccc2C2(C(c3ccccc3)(c3ccccc3)c3ccccc3)N=NN=N2)cc1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 4/20 0.41
AGTR2 P50052 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7301928 0.95 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL7300266 0.90 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL7297201 0.87 AGTR1 (0.39) AGTR1AGTR2
SCHEMBL7301475 0.86 AGTR1 (0.44) AGTR1AGTR2
SCHEMBL7308190 0.85 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL7299367 0.84 AGTR1 (0.39) AGTR1AGTR2
SCHEMBL7310582 0.83 AGTR2 (0.49) AGTR1AGTR2
SCHEMBL7297773 0.83 AGTR1 (0.43) AGTR1AGTR2
SCHEMBL7310297 0.81 AGTR2 (0.47) AGTR1AGTR2
SCHEMBL7306374 0.81 AGTR1 (0.49) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1121859-C Process for preparing pharmaceutical composition for treatment or prevention hypertension SNAKYO CO LTD (JP) 2003-09-24 CN disclosed
EP-0545912-B1 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use SANKYO CO (JP) 2001-04-25 EP disclosed
CN-1188645-A Process for preparing pharmaceutical composition for treatment or prevention hypertension SNAKYO CO LTD (JP) 1998-07-29 CN disclosed
US-5646171-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1997-07-08 US disclosed
US-5616599-A HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
EP-0545912-A2 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1993-06-09 EP disclosed
EP-0503785-A1 1-Biphenylimidazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1992-09-16 EP disclosed