Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | HCK | P08631 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.39 |
| ▸ | PRKDC | P78527 | 4/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.39 |
| ▸ | CFTR | P13569 | 4/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316083 | 0.85 | KDM4E (0.46) | KDRMTORPIK3CAPIK3CDABL1 | |
| SCHEMBL7319490 | 0.73 | MEN1 (0.46) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7312745 | 0.73 | HPGD (0.45) | ALDH1A1HSD17B10HPGD | |
| SCHEMBL7315963 | 0.72 | PIK3CD (0.38) | KDRMTORPIK3CAPIK3CDABL1 | |
| SCHEMBL7310219 | 0.72 | PIK3CD (0.38) | KDRMTORPIK3CAPIK3CDABL1 | |
| SCHEMBL7309931 | 0.70 | S1PR1 (0.37) | KDRMTORPIK3CAPIK3CDABL1 | |
| SCHEMBL7312205 | 0.68 | PIK3CD (0.35) | KDRMTORPIK3CAPIK3CDABL1 | |
| SCHEMBL7316090 | 0.67 | HPGD (0.38) | KDM4EHPGD | |
| SCHEMBL24651098 | 0.66 | RET (0.59) | KDRMTORPIK3CAPIK3CDABL1 | |
| SCHEMBL31359455 | 0.65 | KMT2A (0.57) | KDRMTORPIK3CAPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |