Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
| ▸ | CA2 | P00918 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22362537 | 0.62 | TSHR (0.41) | NPSR1KDM4EXDHTDP1MAPK1 | |
| SCHEMBL7308843 | 0.59 | NPSR1 (0.34) | NPSR1KDM4ETDP1MAPK1NFKB1 | |
| SCHEMBL6727799 | 0.59 | NPSR1 (0.38) | NPSR1KDM4EMAPK1POLBGAA | |
| SCHEMBL7315452 | 0.57 | — | — | |
| SCHEMBL10639650 | 0.57 | TSHR (0.41) | NPSR1KDM4EXDHTDP1LMNA | |
| SCHEMBL10937960 | 0.57 | CHRM3 (0.45) | NPSR1KDM4EXDHTDP1LMNA | |
| SCHEMBL13528338 | 0.57 | NPSR1 (0.46) | NPSR1KDM4EXDHTDP1MAPK1 | |
| SCHEMBL21542487 | 0.57 | KMT2A (0.35) | NPSR1KDM4ETDP1MAPK1POLB | |
| SCHEMBL6850637 | 0.56 | SETD7 (0.51) | NPSR1KDM4EXDHTDP1MAPK1 | |
| SCHEMBL502220 | 0.55 | MAPT (0.38) | NPSR1KDM4ETDP1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5596012-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1997-01-21 | — | — | US | claimed |
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |