Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14558528 | 1.00 | CXCR4 (0.40) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL13587827 | 0.85 | CXCR4 (0.41) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL7475157 | 0.82 | ACE (0.37) | ACEOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL15701685 | 0.81 | CXCR4 (0.47) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL15701679 | 0.81 | CXCR4 (0.46) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL28303172 | 0.81 | MEN1 (0.45) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL29538245 | 0.81 | MEN1 (0.45) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL13337023 | 0.80 | CXCR4 (0.41) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL14603017 | 0.80 | CXCR4 (0.39) | CXCR4ACEOPRM1OPRD1OPRK1 | |
| SCHEMBL15701686 | 0.79 | OPRM1 (0.43) | CXCR4OPRM1MEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901465-B1 | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES | ITALFARMACO SPA (IT) | 2000-09-27 | — | — | EP | disclosed |
| US-6034096-A | Compounds with anti-inflammatory and immunosuppressive activities | ITALFARMACO S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |
| EP-0901465-A1 | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES | ITALFARMACO S.p.A. (IT) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043251-A1 | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES | ITALFARMACO S.P.A. (IT) | 1997-11-20 | — | — | WO | disclosed |