Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309721 | 0.82 | CXCR4 (0.40) | ACEOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL14558528 | 0.82 | CXCR4 (0.40) | ACEOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL6651633 | 0.74 | OPRM1 (0.48) | ACEOPRM1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL6651630 | 0.74 | OPRM1 (0.48) | ACEOPRM1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7475153 | 0.72 | OPRM1 (0.36) | OPRM1OPRD1OPRK1NPSR1ALDH1A1 | |
| SCHEMBL8339942 | 0.72 | OPRM1 (0.36) | OPRM1OPRD1OPRK1NPSR1ALDH1A1 | |
| SCHEMBL20738536 | 0.69 | OPRM1 (0.54) | ACEOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL14067129 | 0.69 | OPRM1 (0.54) | ACEOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL15675696 | 0.69 | OPRM1 (0.54) | ACEOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL6369819 | 0.68 | BCL2 (0.38) | OPRM1OPRD1OPRK1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045844-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1045844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5932590-A | PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1999028314-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |