SCHEMBL7309985

SCHEMBL7309985

COP(C)(=O)OCN1C(=O)c2ccccc2C1=O

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PLIN1 O60240 1/20 0.49
ALDH1A1 P00352 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
PLIN5 Q00G26 1/20 0.49
ABHD5 Q8WTS1 1/20 0.49
ELANE P08246 1/20 0.43
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28492833 0.85 ELANE (0.58) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL13154180 0.80 ALDH1A1 (0.56) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL8163196 0.77 CA12 (0.47) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL28466585 0.77 ELANE (0.59) ELANE
SCHEMBL10441170 0.76 ALDH1A1 (0.50) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL17427523 0.75 HPGD (0.50) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL4124427 0.74 ALDH1A1 (0.53) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL136746 0.73 HPGD (0.53) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL13885122 0.72 ALDH1A1 (0.50) PLIN1ALDH1A1MAPTHPGDALOX15
SCHEMBL571793 0.72 PLIN1 (0.55) PLIN1ALDH1A1MAPTHPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0660840-B1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES CIBA GEIGY AG (CH) 1997-05-07 EP disclosed
WO-1996026729-A1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES AS ECE INHIBITORS CIBA-GEIGY AG (CH) 1996-09-06 WO disclosed
US-5550119-A ENDOTHELIN-CONVERTING ENZYM INHIBITORS CIBA-GEIGY CORPORATION (US) 1996-08-27 US disclosed
EP-0660840-A1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES. CIBA GEIGY AG (CH) 1995-07-05 EP disclosed
EP-0592367-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1994-04-13 EP disclosed
WO-1994005677-A1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES CIBA-GEIGY AG (CH) 1994-03-17 WO disclosed
US-5294632-A Diuretics and vasorelaxants CIBA-GEIGY CORPORATION (US) 1994-03-15 US disclosed
US-5250522-A Neutral endopeptidase inhibitors; cardiovascular disorders CIBA-GEIGY CORPORATION (US) 1993-10-05 US disclosed
EP-0511940-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1992-11-04 EP disclosed
US-5155100-A Treating cardiovascular disorders in mammals CIBA-GEIGY CORPORATION (US) 1992-10-13 US disclosed