PLIN1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL20846	1.00	2/20
SCHEMBL22146	1.00	2/20
Menadione (SCHEMBL25970)	1.00	2/20
SCHEMBL28181	1.00	2/20
SCHEMBL478244	1.00	2/20
SCHEMBL5111	0.95	2/20
SCHEMBL9619	0.95	2/20
SCHEMBL19685	0.95	2/20
SCHEMBL97495	0.95	2/20
SCHEMBL97496	0.95	2/20
SCHEMBL155137	0.95	2/20
SCHEMBL187662	0.95	2/20
Water (SCHEMBL424880)	0.86	2/20
Chloroform (SCHEMBL84057)	0.79	2/20
SCHEMBL184544	0.75	2/20
Cinnamic Acid (SCHEMBL1332)	0.73	2/20
Cinnamic Acid (SCHEMBL1333)	0.73	2/20
Cinnamic Acid (SCHEMBL50466)	0.73	2/20
SCHEMBL243733	0.71	2/20
SCHEMBL243734	0.71	2/20

Clinical trials — most relevant to PLIN1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Ipragliflozin on Excessive Fat in Type 2 Diabetes Patients With Non-alcoholic Fatty Liver Disease Treated With Metformin and Pioglitazone	PHASE4	COMPLETED
Mechanisms Underlying Metabolic Syndrome in Obesity	PHASE4	COMPLETED
Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes	PHASE4	COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy	PHASE2	COMPLETED
Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects	PHASE2	COMPLETED
Insulin Regulation of Lipolysis and Lipolysis Proteins	EARLY_PHASE1	RECRUITING
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Association of Genes to Resistance to Weight Loss in Obese Patients	nan	COMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Familial Partial Lipodystrophy Study	nan	COMPLETED
Efficacy of Sodium Glucose Cotransporter 2 Inhibitors on Non-Alcoholic Fatty Liver Disease	nan	NOT_YET_RECRUITING
MARS: Magnetic Resonance Study: A Novel Assessment of Placental Function	nan	COMPLETED
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
The Role of Ectopic Fat and Heart Attack Risk in HIV	nan	RECRUITING
Serum Adipokines and Metabolic Parameters With Hormone Replacement in Newly Diagnosed Hypothyroidism	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS)	nan	NOT_YET_RECRUITING
The Project ATA: Adipose Tissue & Adipokines	nan	UNKNOWN
Evaluation of Endocrine and Metabolic Parameters in the New Diagnostic Phenotypes of Polycystic Ovary Syndrome	nan	UNKNOWN
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation	nan	COMPLETED
Hepatic Glycogen and Fat Oxidation	nan	COMPLETED
for Adipose Tissue DIabetes VAriants (fATDIVA)	nan	COMPLETED
Lipodystrophy Connect Patient Registry	nan	COMPLETED
Mechanisms of the Effect of Physical Activity on the Adaptation to a High-Fat Diet	nan	COMPLETED
Normal Serum Adiponectin Levels in Females	nan	UNKNOWN
Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea	nan	COMPLETED
Omega-3 Supplementation Decreases Inflammation and Fetal Obesity in Pregnancy	nan	COMPLETED
Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a PLIN1 binder may also engage these)

Protein	Name	Similarity
Q8CGN5	—	1.000	Q8CGN5 →
P43884	—	1.000	P43884 →
M0R7Z9	—	0.994	M0R7Z9 →
Q8BVZ1	—	0.991	Q8BVZ1 →
A6QLL0	—	0.990	A6QLL0 →
B0FJL7	—	0.988	B0FJL7 →
PLIN5	Perilipin-5 (Lipid storage droplet protein 5)	0.986	landscape →
P02655	—	0.982	P02655 →
Q8R1X6	—	0.980	Q8R1X6 →
P0DTS5	—	0.980	P0DTS5 →
Q6WN19	—	0.980	Q6WN19 →
P0DUP3	—	0.980	P0DUP3 →
O54724	—	0.978	O54724 →
P0DP52	—	0.977	P0DP52 →
O70622	—	0.977	O70622 →
Q8VDP4	—	0.977	Q8VDP4 →
Q6NZI2	—	0.977	Q6NZI2 →
Q8K330	—	0.977	Q8K330 →
Q0VCT2	—	0.977	Q0VCT2 →
Q7TNI2	—	0.977	Q7TNI2 →
Q9P1Y5	—	0.977	Q9P1Y5 →
P0DTS3	—	0.977	P0DTS3 →
A1L3T7	—	0.977	A1L3T7 →
P18658	—	0.976	P18658 →
Q6DGF9	—	0.976	Q6DGF9 →
P0DTR8	—	0.976	P0DTR8 →
A0A096P2H4	—	0.976	A0A096P2H4 →
P0DUX9	—	0.976	P0DUX9 →
Q7TNY7	—	0.976	Q7TNY7 →
Q9CQV4	—	0.976	Q9CQV4 →