SCHEMBL7310020

SCHEMBL7310020

O=[N+]([O-])/C=C1/C[N+]([O-])=C(c2ccccc2F)c2cc(Cl)ccc2N1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.43
CHRM1 P11229 7/20 0.41
CCNE2 O96020 1/20 0.37
CCNE1 P24864 1/20 0.37
CDK2 P24941 1/20 0.37
CHRM5 P08912 1/20 0.35
LRRK2 Q5S007 1/20 0.34
TRPV1 Q8NER1 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7310022 1.00 LMNA (0.43) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL7310681 0.88 NPC1 (0.33) LRRK2
SCHEMBL7308432 0.88 MEN1 (0.41) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL7308428 0.88 MEN1 (0.41) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL7306150 0.86 CYP1A2 (0.42) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL7306143 0.86 CYP1A2 (0.42) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL11319239 0.81 LMNA (0.57) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL7308167 0.78 LMNA (0.65) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL31150951 0.78 LMNA (0.65) LMNACHRM1CCNE2CCNE1CDK2
SCHEMBL7308162 0.78 LMNA (0.65) LMNACHRM1CCNE2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4440685-A MUSCLE RELAXANTS, SEDATIVES, ANTICONVULSANTS HOFFMANN-LA ROCHE INC. (US) 1984-04-03 US disclosed
US-4425272-A ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1984-01-10 US disclosed
US-4401597-A INTERMEDIATES FOR ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVE AND ANXIOLYTICS HOFFMANN-LA ROCHE INC. (US) 1983-08-30 US disclosed
US-4390471-A INTERMEDIATES FOR IMIDOBENZODIAZEPINE AND ANALOGS HOFFMANN-LA ROCHE INC. (US) 1983-06-28 US disclosed
US-4377523-A Imidazodiazepines and processes therefor HOFFMANN-LA ROCHE INC. (US) 1983-03-22 US disclosed
US-4376075-A REACTION OF AN AMINODERIVATIVE THEREOF WITH AN ALDEHYDE HOFFMANN-LA ROCHE INC. (US) 1983-03-08 US disclosed
US-4376074-A ANTICONVULSANTS, MUSCLE RELAXANTS AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-03-08 US disclosed
US-4371468-A ANTICONVULSANTS, MUSCLE RELAXANTS, AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-02-01 US disclosed
US-4368159-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4368158-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4280957-A Imidazodiazepines and processes therefor HOFFMANN-LA ROCHE INC. (US) 1981-07-28 US disclosed
US-4259241-A Process for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1981-03-31 US disclosed
US-4257946-A Benzodiazepine intermediates for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1981-03-24 US disclosed
US-4250095-A Imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1981-02-10 US disclosed
US-4247463-A Process for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1981-01-27 US disclosed
US-4244868-A Process for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1981-01-13 US disclosed
US-4244867-A Process for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1981-01-13 US disclosed
US-4240962-A Process for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1980-12-23 US disclosed
US-4226771-A 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives HOFFMANN-LA ROCHE INC. (US) 1980-10-07 US disclosed
US-4226768-A Process for the preparation of imidazobenzodiazepines HOFFMANN-LA ROCHE INC. (US) 1980-10-07 US disclosed