Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.71 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554098 | 0.83 | NOTUM (1.00) | NOTUMOPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL17382966 | 0.83 | NOTUM (1.00) | NOTUMOPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL21839107 | 0.83 | NOTUM (1.00) | NOTUMOPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL29896718 | 0.83 | NOTUM (1.00) | NOTUMOPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL16589999 | 0.79 | SRD5A1 (0.51) | NOTUMSRD5A1 | |
| SCHEMBL7340995 | 0.79 | NOTUM (0.49) | NOTUMSRD5A1OPRM1OPRK1HTR2B | |
| SCHEMBL16587000 | 0.79 | NOTUM (0.49) | NOTUMSRD5A1OPRM1OPRK1OPRL1 | |
| SCHEMBL7378144 | 0.79 | NOTUM (0.49) | NOTUMSRD5A1OPRM1OPRK1HTR2B | |
| SCHEMBL7372067 | 0.79 | NOTUM (0.49) | NOTUMSRD5A1OPRM1OPRK1HTR2B | |
| SCHEMBL31091227 | 0.77 | NOTUM (0.56) | NOTUMSRD5A1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699680-B1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SANOFI SYNTHELABO (FR) | 2000-03-08 | — | — | EP | claimed |
| US-5641785-A | ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-06-24 | — | — | US | claimed |
| EP-0699680-A1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1996-03-06 | — | — | EP | claimed |
| WO-2015040424-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS | VERNALIS (R&D) LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| EP-1210080-A2 | USE OF MONOAMINE OXIDASE INHIBITORS FOR THE MANUFACTURE OF DRUGS INTENDED FOR THE TREATMENT OF OBESITY | Sanofi-Aventis (FR) | 2002-06-05 | — | — | EP | disclosed |
| EP-1078632-A1 | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity | SANOFI-SYNTHELABO (FR) | 2001-02-28 | — | — | EP | disclosed |
| WO-2001012176-A2 | USE OF MONOAMINE OXIDASE INHIBITORS FOR THE MANUFACTURE OF DRUGS INTENDED FOR THE TREATMENT OF OBESITY | SANOFI-SYNTHELABO (FR) | 2001-02-22 | — | — | WO | disclosed |
| CN-1055472-C | Oxazoloquinolinone derivatives, their preparation and their therapeutic use | SYNTHELABO (FR) | 2000-08-16 | — | — | CN | disclosed |
| EP-0699680-B1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SANOFI SYNTHELABO (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5641785-A | ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-06-24 | — | — | US | disclosed |
| US-5641785-A | ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-06-24 | — | — | US | disclosed |
| CN-1128763-A | Oxazoloquinolinone derivatives, their preparation and their therapeutic use | SYNTHELABO (FR) | 1996-08-14 | — | — | CN | disclosed |
| EP-0699680-A1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1996-03-06 | — | — | EP | disclosed |
| EP-0699680-A1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1996-03-06 | — | — | EP | disclosed |