Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | PDE9A | O76083 | 6/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315963 | 0.75 | PIK3CD (0.38) | PIK3CAMTORPIK3CGMAPK14PIK3CD | |
| SCHEMBL7310219 | 0.75 | PIK3CD (0.38) | PIK3CAMTORS1PR1PIK3CGPIK3CD | |
| SCHEMBL7316083 | 0.73 | KDM4E (0.46) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL7312205 | 0.73 | PIK3CD (0.35) | PIK3CAMTORPIK3CGMAPK14PIK3CD | |
| SCHEMBL7309931 | 0.72 | S1PR1 (0.37) | PIK3CAMTORS1PR1PIK3CGPIK3CD | |
| SCHEMBL7317167 | 0.72 | HPGD (0.43) | LATS1LATS2 | |
| SCHEMBL19362509 | 0.69 | EGFR (0.59) | PIK3CAMTORPIK3CGMAPK14PIK3CD | |
| SCHEMBL29617733 | 0.69 | EGFR (0.59) | PIK3CAMTORPIK3CGMAPK14PIK3CD | |
| SCHEMBL5805364 | 0.69 | BTK (0.51) | PIK3CAMTORPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL31037237 | 0.68 | EGFR (0.58) | PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |