SCHEMBL7311367

SCHEMBL7311367

N#Cc1ccc(Cc2ccc(O)cc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.73
CA2 P00918 1/20 0.73
CA3 P07451 1/20 0.73
CA6 P23280 1/20 0.73
CA9 Q16790 1/20 0.73
CA14 Q9ULX7 1/20 0.73
MMP3 P08254 1/20 0.64
ESR1 P03372 2/20 0.64
ESR2 Q92731 2/20 0.64
SAE1 Q9UBE0 1/20 0.56
UBA2 Q9UBT2 1/20 0.56
LOXL2 Q9Y4K0 2/20 0.54
CYP2A6 P11509 1/20 0.52
CYP19A1 P11511 4/20 0.49
HRH3 Q9Y5N1 1/20 0.46
IDO1 P14902 2/20 0.46
P4HB P07237 1/20 0.43
HTT P42858 1/20 0.43
PTPN1 P18031 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1344068 0.88 LOXL2 (0.65) CA12CA2CA3CA6CA9
SCHEMBL10355508 0.86 CA2 (0.73) CA12CA2CA3CA6CA9
4-Cyanophenol SCHEMBL27294505 0.85 CA2 (1.00) CA12CA2CA3CA6CA9
4-Cyanophenol SCHEMBL28811803 0.85 CA2 (1.00) CA12CA2CA3CA6CA9
4-Cyanophenol SCHEMBL50814 0.85
4-Cyanophenol SCHEMBL27413520 0.83 CA2 (0.94) CA12CA2CA3CA6CA9
4-Cyanophenol SCHEMBL10685886 0.83 CA2 (0.94) CA12CA2CA3CA6CA9
4-Cyanophenol SCHEMBL7393582 0.83 CA2 (0.94) CA12CA2CA3CA6CA9
4-Cyanophenol SCHEMBL28089570 0.83 CA2 (0.94) CA12CA2CA3CA6CA9
SCHEMBL31591073 0.82 SAE1 (0.56) CA12CA2CA3CA6CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927035-A4 THROMBIN INHIBITORS MERCK & CO INC (US) 2002-11-13 EP disclosed
US-6242654-B1 REACTING A PHENOLATE COMPOUND WITH AN ORGANIC FLUORINATING AGENT TO PREPARE A FLUORINE SUBSTITUTED AROMATIC COMPOUND MITSUI CHEMICALS, INC. (JP) 2001-06-05 US disclosed
EP-1013629-A1 Preparation process of fluorine subsituted aromatic compound Mitsui Chemicals, Inc. (JP) 2000-06-28 EP disclosed
EP-0927035-A1 THROMBIN INHIBITORS Merck & Co., Inc. (US) 1999-07-07 EP disclosed
US-5872138-A INHIBITING LOSS OF BLOOD PLATELETS, INHIBITING FORMATION OF BLOOD PLATELET AGGREGATES, INHIBITING FORMATION OF FIBRIN, INHIBITING THROMBUS FORMATION, AND INHIBITING EMBOLUS FORMATION IN A MAMMAL MERCK & CO., INC. (US) 1999-02-16 US disclosed
WO-1998010763-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 1998-03-19 WO disclosed