Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4208427 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| SCHEMBL10671842 | 0.77 | NR4A2 (0.46) | KDM4EALDH1A1SMN1; SMN2NR4A2ATM | |
| SCHEMBL1557504 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| SCHEMBL28855043 | 0.76 | HSD17B10 (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| SCHEMBL2592358 | 0.72 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| SCHEMBL13485706 | 0.71 | KMT2A (0.50) | KDM4EALDH1A1SMN1; SMN2MAPTATM | |
| SCHEMBL2006899 | 0.71 | AHR (0.57) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| SCHEMBL6526599 | 0.70 | GSK3B (0.56) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| SCHEMBL12613819 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2MAPTNR4A2 | |
| Carbazole SCHEMBL3692485 | 0.69 | ALDH1A1 (0.78) | KDM4EALDH1A1SMN1; SMN2MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845092-A | OF VISCERAL PAIN IN MAMMALS, HUMANS | BEECHAM GROUP PLC (GB) | 1989-07-04 | — | — | US | claimed |
| US-4789673-A | ANTISEROTONINE AGENTS | NOVARTIS AG (CH) | 1988-12-06 | — | — | US | claimed |
| EP-0279512-A2 | Use of certain 5-HT3 receptor antagonists in the treatment of visceral pain | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | claimed |
| US-4845092-A | OF VISCERAL PAIN IN MAMMALS, HUMANS | BEECHAM GROUP PLC (GB) | 1989-07-04 | — | — | US | disclosed |
| US-4789673-A | ANTISEROTONINE AGENTS | NOVARTIS AG (CH) | 1988-12-06 | — | — | US | disclosed |
| EP-0279512-A2 | Use of certain 5-HT3 receptor antagonists in the treatment of visceral pain | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | disclosed |