SCHEMBL7311642

SCHEMBL7311642

CN(C)CCCOc1ccc(C[C@H](NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)s2)C(=O)O)cc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 1/20 0.50
MMP12 P39900 1/20 0.50
MMP13 P45452 1/20 0.50
ITGB1 P05556 11/20 0.49
ITGA4 P13612 4/20 0.49
ITGB7 P26010 1/20 0.49
ITGA5 P08648 4/20 0.48
ALDH1A1 P00352 1/20 0.47
ITGAV P06756 5/20 0.43
UTS2R Q9UKP6 1/20 0.42
TRPA1 O75762 1/20 0.41
ITGB3 P05106 2/20 0.40
ITGA2B P08514 2/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7452943 0.90 ITGA4 (0.49) MMP8MMP12MMP13ITGB1ITGA4
SCHEMBL7326216 0.88 ITGB1 (0.49) ITGB1ITGA4ITGB7ITGA5ITGAV
SCHEMBL7315537 0.87 ITGB1 (0.50) ITGB1ITGA4ITGB7ITGA5ITGAV
SCHEMBL7315770 0.84 ITGA4 (0.59) MMP13ITGB1ITGA4ITGB7ITGA5
SCHEMBL7073204 0.84 ITGB1 (0.60) MMP13ITGB1ITGA4ITGB7ITGA5
SCHEMBL7319192 0.83 ITGB1 (0.48) ITGB1ITGA4ITGB7ITGA5ITGAV
SCHEMBL6374041 0.83 MMP8 (0.60) MMP8MMP12MMP13ITGB1ITGA4
SCHEMBL7318950 0.82 ITGB1 (0.46) ITGB1ITGA4ITGB7ITGA5ITGAV
SCHEMBL7324679 0.82 ITGB1 (0.51) MMP13ITGB1ITGA4ITGB7ITGA5
SCHEMBL7325939 0.82 ITGB1 (0.48) MMP8ITGB1ITGA4ITGB7ITGA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US claimed
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP claimed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO claimed
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US disclosed
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP disclosed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed