Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435978 | 1.00 | POLB (0.50) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL9209868 | 1.00 | POLB (0.50) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7302074 | 1.00 | POLB (0.50) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7302081 | 1.00 | POLB (0.50) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7287025 | 0.91 | KDM4E (0.46) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7287036 | 0.91 | KDM4E (0.46) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL9076449 | 0.91 | POLB (0.50) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7322502 | 0.90 | TDP1 (0.54) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7324499 | 0.90 | TDP1 (0.54) | POLBKDM4EUSP2ESR1THRB | |
| SCHEMBL7324505 | 0.90 | TDP1 (0.54) | POLBKDM4EUSP2ESR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6298750-A | — | — | None | — | — | JP | disclosed |
| EP-0615971-B1 | 5-(Piperazinylalkyl)-1,5-benzothiazepinones useful as calcium antagonists | SHIONOGI & CO (JP) | 1997-08-13 | — | — | EP | disclosed |
| EP-0415384-B1 | Heterogeneous synthesis of azepinones from esters | HOECHST MARION ROUSSEL INC (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5462936-A | Administering for treatment of hypertension and ischemic diseases | SHIONOGI & CO., LTD. (JP) | 1995-10-31 | — | — | US | disclosed |
| EP-0429060-B1 | Benzothiazepines | MARION MERRELL DOW INC (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0541263-B1 | 5-piperazinylalkyl-1,5-benzothiazepinones useful as calcium antagonists | SHIONOGI & CO (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0395302-B1 | Process for preparing 1,5-benzothiazepine derivatives | TANABE SEIYAKU CO (JP) | 1995-01-04 | — | — | EP | disclosed |
| US-5378698-A | Hypotensive and antiischemic agents | SHIONOGI & CO., LTD. (JP) | 1995-01-03 | — | — | US | disclosed |
| JP-H06298750-A | PRODUCTION OF 1,5-BENZOTHIAZEPIN DERIVATIVE | TANABE SEIYAKU CO LTD | 1994-10-25 | — | — | JP | disclosed |
| EP-0615971-A1 | 5-(Piperazinylalkyl)-1,5-benzothiazepinones useful as calcium antagonists | SHIONOGI & CO., LTD. (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5001236-A | Benzothiazepines | MARION LABORATORIES, INC. (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0416479-A1 | 1,5-Benzothiazepine derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-13 | — | — | EP | disclosed |
| EP-0415384-A2 | Heterogeneous synthesis of azepinones from esters | HOECHST MARION ROUSSEL, INC. (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0395302-A1 | Process for preparing 1,5-benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |
| EP-0158339-B1 | 1,5-BENZOTHIAZEPHINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS | Tanabe Seiyaku Co., Ltd. (JP) | 1989-01-18 | — | — | EP | disclosed |
| EP-0127882-B1 | NOVEL 8-CHLORO-1,5-BENZOTHIAZEPINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS | Tanabe Seiyaku Co., Ltd. (JP) | 1986-10-15 | — | — | EP | disclosed |
| US-4585768-A | ANTICOAGULANTS | TANABE SEIYAKU CO., LTD. (JP) | 1986-04-29 | — | — | US | disclosed |
| US-4567175-A | HYPOTENSIVE AGENTS, CORONARY OR CEREBRAL VASODILATORS | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| EP-0158339-A2 | 1,5-Benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-10-16 | — | — | EP | disclosed |
| EP-0127882-A1 | Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1984-12-12 | — | — | EP | disclosed |