Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 9/20 | 0.48 |
| ▸ | CASP8 | Q14790 | 8/20 | 0.48 |
| ▸ | CASP1 | P29466 | 5/20 | 0.48 |
| ▸ | CASP7 | P55210 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311888 | 1.00 | CTSD (0.48) | CTSDCASP3CASP8CASP1CASP7 | |
| SCHEMBL7310887 | 0.90 | CTSL (0.51) | — | |
| SCHEMBL7310877 | 0.90 | CTSL (0.51) | — | |
| SCHEMBL7305148 | 0.90 | CTSL (0.47) | CASP3CASP8CASP1CASP7 | |
| SCHEMBL7305141 | 0.90 | CTSL (0.47) | CASP3CASP8CASP1CASP7 | |
| SCHEMBL7347081 | 0.90 | TACR1 (0.49) | CASP1 | |
| SCHEMBL7347088 | 0.90 | TACR1 (0.49) | CASP1 | |
| SCHEMBL7307053 | 0.89 | CAPN1 (0.57) | — | |
| SCHEMBL7304428 | 0.89 | CAPN1 (0.57) | — | |
| SCHEMBL7304416 | 0.89 | CAPN1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |