Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.35 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.35 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311901 | 1.00 | REN (0.39) | RENCYP3A4TDP1LYPLA1LYPLA2 | |
| SCHEMBL16369589 | 0.81 | REN (0.47) | REN | |
| SCHEMBL15908018 | 0.81 | REN (0.47) | REN | |
| SCHEMBL22045827 | 0.80 | REN (0.47) | REN | |
| SCHEMBL462322 | 0.79 | REN (0.50) | REN | |
| SCHEMBL21986306 | 0.79 | REN (0.46) | REN | |
| SCHEMBL13336547 | 0.79 | REN (0.46) | REN | |
| SCHEMBL3947837 | 0.79 | REN (0.50) | REN | |
| SCHEMBL2428900 | 0.79 | REN (0.46) | REN | |
| SCHEMBL19304577 | 0.79 | REN (0.50) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678503-A1 | Delta-amino-gamma-hydroxy-omega-aryl alkanoic acid amides with enzyme especially renin inhibiting activities | CIBA-GEIGY AG (CH) | 1995-10-25 | — | — | EP | claimed |