Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | REN | P00797 | 13/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872157 | 1.00 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL9819695 | 1.00 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL5847958 | 1.00 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7401954 | 1.00 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL13134807 | 1.00 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL12161411 | 0.96 | CTSK (0.51) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL2809379 | 0.96 | CTSK (0.51) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL8278577 | 0.93 | CTSK (0.53) | CTSSCTSKRENCA1CA2 | |
| SCHEMBL10407741 | 0.89 | CTSS (0.53) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL6477320 | 0.88 | CTSK (0.49) | CTSSCTSKRENCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376649-B1 | REACTING A N-TERMINALLY BLOCKED AMINOALDEHYDE WITH AN ISONITRILE AND A CARBOXYLIC ACID TO GIVE AN AMINO-ALPHA-ACYLOXYCARBOXAMIDE; REMOVING THE ACYLOXY GROUP, OR REMOVING THE PROTECTING GROUP GIVE THE DERIVATIVE. | CORVAS INTERNATIONAL, INC. | 2002-04-23 | — | — | US | disclosed |
| EP-1140854-A2 | METHODS FOR THE SYNTHESIS OF ALPHA-HYDROXY-BETA-AMINO ACID AND AMIDE DERIVATIVES | CORVAS INTERNATIONAL, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035868-A2 | METHODS FOR THE SYNTHESIS OF ALPHA-HYDROXY-BETA-AMINO ACID AND AMIDE DERIVATIVES | CORVAS INTERNATIONAL, INC. (US) | 2000-06-22 | — | — | WO | disclosed |
| US-5135914-A | Controlling hypertension, hyperaldosteronism, and congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| US-4668769-A | Oxa- and azahomocyclostatine polypeptides | PFIZER INC. | 1987-05-26 | — | — | US | disclosed |
| EP-0211580-A2 | Renin inhibiting polypeptides and intermediates therefor | PFIZER INC. (US) | 1987-02-25 | — | — | EP | disclosed |
| US-4599198-A | Intermediates in polypeptide synthesis | PFIZER INC. (US) | 1986-07-08 | — | — | US | disclosed |