Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7316393 | 0.87 | SLC6A9 (0.51) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL7310725 | 0.84 | SLC6A2 (0.50) | KDM4EALDH1A1SLC6A4ADRA2AADRA2B | |
| Succinic Acid SCHEMBL175860 | 0.83 | SLC6A9 (0.43) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 | |
| SCHEMBL7169436 | 0.81 | SLC6A4 (0.52) | SLC6A9SLC6A4HRH3ADRA2BKCNH2 | |
| Oxalic Acid SCHEMBL7317340 | 0.80 | KDM4E (0.69) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL5033726 | 0.80 | CYP1A2 (0.57) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 | |
| SCHEMBL8026016 | 0.80 | SLC6A4 (0.51) | SLC6A9SLC6A4HRH3ADRA2BKCNH2 | |
| Oxalic Acid SCHEMBL7314749 | 0.79 | KDM4E (0.56) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL7310142 | 0.79 | SLC6A9 (0.51) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 | |
| SCHEMBL8027901 | 0.79 | SLC6A9 (0.48) | SLC6A9KDM4EALDH1A1SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |