Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 13/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 5/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358963 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL10353452 | 0.86 | SMN1; SMN2 (0.81) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL7298599 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL7304108 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL9631025 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL9686065 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL8339349 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL10745652 | 0.81 | PDE3B (0.65) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL2846257 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL21969533 | 0.81 | MAPT (0.63) | SMN1; SMN2PDE3BPDE3AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001000590-A1 | SUBSTITUTED 6-[4-(OXYMETHYL)-PHENYL]-DIHYDROPYRIDAZINONES AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-04 | — | — | WO | disclosed |
| EP-0308785-B1 | DIHYDROPYRIDINE ETHERS, PROCESSES FOR THEIR PREPARATION AND THEIR UTILISATION | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| US-4886804-A | HYPERTENSIVE, CARDIOTONIC, HYPERGLYCEMIC, ANTIARRHYTHMIA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4876255-A | CARDIOVASCULAR | BAYER AKTIENGESELLSCHAFT (DE) | 1989-10-24 | — | — | US | disclosed |
| US-4876254-A | CARDIOVASCULAR DISORDERS, HYPERTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-10-24 | — | — | US | disclosed |
| EP-0308785-A2 | Dihydropyridine ethers, processes for their preparation and their utilisation | BAYER AG (DE) | 1989-03-29 | — | — | EP | disclosed |
| EP-0287867-A1 | Substituted 5-nitro-1,4-dihydropyridines, method for their preparation and their use | BAYER AG (DE) | 1988-10-26 | — | — | EP | disclosed |
| EP-0287866-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use | BAYER AG (DE) | 1988-10-26 | — | — | EP | disclosed |