Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315407 | 0.73 | PDE3B (0.46) | PDE3BPDE3ANPC1GAAATM | |
| SCHEMBL7431362 | 0.64 | MAPT (0.63) | NPC1GAAALDH1A1KMT2AMAPT | |
| SCHEMBL28268521 | 0.63 | PTPN1 (0.46) | PDE3BPDE3ANPC1GAAATM | |
| SCHEMBL17578806 | 0.62 | ALOX5 (0.49) | PDE3BPDE3AALDH1A1KMT2AMEN1 | |
| Perchlorate SCHEMBL7307126 | 0.62 | SMN1; SMN2 (0.38) | NPC1RXFP1ALDH1A1MAPTKDM4E | |
| SCHEMBL7305966 | 0.61 | PDE3B (0.57) | PDE3BPDE3AGAABACE1ALDH1A1 | |
| SCHEMBL8777227 | 0.60 | PDE3B (0.49) | PDE3BPDE3AALDH1A1KMT2AMAPT | |
| SCHEMBL7408029 | 0.58 | ALOX5 (0.47) | PDE3BPDE3AALDH1A1KMT2AMEN1 | |
| SCHEMBL7307946 | 0.58 | PDE3B (0.54) | PDE3BPDE3ABACE1KDM4E | |
| SCHEMBL7320313 | 0.58 | ALOX5 (0.47) | PDE3BPDE3AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |
| US-4822800-A | Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-04-18 | — | — | US | disclosed |