Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305966 | 0.84 | PDE3B (0.57) | PDE3BPDE3AGAABACE1TSHR | |
| SCHEMBL7307946 | 0.76 | PDE3B (0.54) | PDE3BPDE3ABACE1TSHRKDM4E | |
| SCHEMBL7319852 | 0.75 | HPGD (0.37) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| Perchlorate SCHEMBL7312607 | 0.73 | PDE3B (0.43) | PDE3BPDE3ADPP4NPC1GAA | |
| SCHEMBL7311043 | 0.73 | PDE3B (0.50) | PDE3BPDE3ADPP4NPC1BACE1 | |
| SCHEMBL7315403 | 0.72 | SLC10A2 (0.37) | DPP4GAATUBB4ATUBBTUBA3C | |
| SCHEMBL7313861 | 0.72 | PDE3B (0.44) | PDE3BPDE3ADPP4GAAMAPT | |
| SCHEMBL7317446 | 0.72 | TP53 (0.44) | PDE3BPDE3AMAPTALDH1A1KDM4E | |
| SCHEMBL7309250 | 0.70 | PDE3B (0.44) | PDE3BPDE3ADPP4GAATSHR | |
| SCHEMBL7319613 | 0.70 | ALDH1A1 (0.41) | PDE3BPDE3ANPC1ATMRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822800-A | Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-04-18 | — | — | US | disclosed |