Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478016 | 0.85 | TDP1 (0.44) | MAPTKMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL10666257 | 0.83 | ALDH1A1 (0.45) | MAPTKMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL10823922 | 0.81 | ALDH1A1 (0.41) | MAPTKMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL10667981 | 0.78 | KCNH2 (0.43) | MAPTKMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL10663288 | 0.77 | ALDH1A1 (0.41) | MAPTKMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL10727147 | 0.77 | MAPT (0.48) | MAPTKMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10823909 | 0.75 | KMT2A (0.40) | MAPTKMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL8072110 | 0.71 | ALDH1A1 (0.44) | MAPTKMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10543420 | 0.71 | L3MBTL1 (0.39) | MAPTKMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4153261 | 0.71 | ALDH1A1 (0.42) | MAPTKMT2ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229644-A2 | Method of use for diltiazem, verapamil or nifedipine having activity for the treatment of stroke | WARNER-LAMBERT COMPANY (US) | 1987-07-22 | — | — | EP | disclosed |