Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312788 | 0.86 | REN (0.46) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7366211 | 0.80 | REN (0.55) | REN | |
| Histidine SCHEMBL10660498 | 0.80 | ACE (0.56) | RENMAPK1POLBMAPTTDP1 | |
| Histidine SCHEMBL10661313 | 0.78 | ACE (0.45) | RENMAPK1ACEPSEN1PSEN2 | |
| SCHEMBL7316247 | 0.78 | REN (0.44) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7315462 | 0.78 | REN (0.44) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7317391 | 0.78 | REN (0.44) | RENMAPK1POLBMAPTATM | |
| SCHEMBL28846075 | 0.77 | ACE (0.53) | RENMAPK1POLBMAPTTDP1 | |
| SCHEMBL7319704 | 0.77 | REN (0.41) | REN | |
| SCHEMBL7319700 | 0.77 | REN (0.41) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |