Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823210 | 0.87 | MMP1 (0.59) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6824575 | 0.84 | PDE4A (0.51) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7300405 | 0.84 | MME (0.50) | MMP1HDAC6 | |
| SCHEMBL6823237 | 0.83 | PDE4A (0.53) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7302523 | 0.82 | MMP1 (0.54) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7298887 | 0.82 | ANPEP (0.52) | MMP2MMP9MMP8 | |
| SCHEMBL7299278 | 0.81 | PPARG (0.47) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6819843 | 0.81 | PDE4A (0.53) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7362100 | 0.80 | PDE4A (0.57) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7301205 | 0.79 | MME (0.46) | MMP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1177821-C | Matrix metalloprotease inhibitors | - | 2004-12-01 | — | — | CN | disclosed |
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| CN-1160045-A | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 1997-09-24 | — | — | CN | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |