Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 7/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306329 | 0.88 | MMP1 (0.53) | MMP2MMP9MMP3MMP1PDE4A | |
| SCHEMBL7308114 | 0.81 | MMP2 (0.44) | MMP2MMP9ADAMTS4MMP3MMP1 | |
| SCHEMBL11828010 | 0.72 | MMP2 (0.50) | CPA1CPB1CPA3CPB2MMP2 | |
| SCHEMBL11827616 | 0.71 | MMP2 (0.49) | CPA1CPB1CPA3CPB2MMP2 | |
| SCHEMBL11837183 | 0.71 | MMP2 (0.49) | MMP2MMP9ADAMTS4MMP12MMP13 | |
| SCHEMBL7302926 | 0.70 | CPA1 (0.44) | CPA1CPB1CPA3CPB2MMP2 | |
| SCHEMBL27477106 | 0.70 | PPARG (0.52) | CPA1CPB1CPA3CPB2MMP2 | |
| SCHEMBL27611646 | 0.70 | CPA1 (0.58) | CPA1CPB1CPA3CPB2MIF | |
| SCHEMBL7313243 | 0.69 | MMP2 (0.51) | CPA1CPB1CPA3CPB2MMP2 | |
| SCHEMBL27477107 | 0.69 | PTPRC (0.39) | CPA1CPB1CPA3CPB2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |