Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.47 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314653 | 0.91 | SLC6A1 (0.46) | KIF11SLC6A1SLC1A5CYP1A2CYP2C19 | |
| SCHEMBL7317519 | 0.91 | SLC6A1 (0.46) | KIF11SLC6A1SLC1A5CYP1A2CYP2C19 | |
| SCHEMBL7311726 | 0.88 | KIF11 (0.47) | KIF11SLC6A1SLC1A5CYP1A2CYP2C19 | |
| SCHEMBL7318344 | 0.88 | KIF11 (0.47) | KIF11SLC6A1SLC1A5CYP1A2CYP2C19 | |
| SCHEMBL7326122 | 0.86 | KIF11 (0.59) | KIF11SLC6A1SLC1A5CYP1A2CYP2C19 | |
| SCHEMBL7322275 | 0.81 | KIF11 (0.40) | KIF11SLC6A1SLC1A5 | |
| SCHEMBL7320451 | 0.81 | KIF11 (0.40) | KIF11SLC6A1SLC1A5 | |
| SCHEMBL7313597 | 0.78 | KIF11 (0.49) | KIF11SLC6A1SLC1A5CYP1A2CYP2C19 | |
| SCHEMBL7326222 | 0.78 | KIF11 (0.39) | KIF11SLC6A1CYP1A2CYP2C19 | |
| SCHEMBL7326219 | 0.78 | KIF11 (0.39) | KIF11SLC6A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |