SCHEMBL7313388

SCHEMBL7313388

COC(=O)c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1

nearest known ligand 0.77

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PLAU P00749 5/20 0.77
TCF4 P15884 2/20 0.73
CTNNB1 P35222 2/20 0.73
PLAT P00750 1/20 0.64
AKR1C3 P42330 1/20 0.63
SMN1; SMN2 Q16637 3/20 0.61
ALDH1A1 P00352 2/20 0.61
LMNA P02545 2/20 0.61
GAA P10253 1/20 0.61
POLB P06746 2/20 0.60
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
MAPT P10636 1/20 0.57
HTT P42858 1/20 0.57
PKM P14618 1/20 0.56
PKLR P30613 1/20 0.56
ATM Q13315 1/20 0.56
KAT6A Q92794 1/20 0.54
PGR P06401 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6078100 0.89 TCF4 (0.68) PLAUTCF4CTNNB1PLATAKR1C3
SCHEMBL6078558 0.88 TCF4 (0.65) PLAUTCF4CTNNB1PLATSMN1; SMN2
SCHEMBL7319886 0.88 LMNA (0.69) PLAUTCF4CTNNB1AKR1C3SMN1; SMN2
SCHEMBL7311403 0.85 AKR1C3 (0.85) PLAUAKR1C3SMN1; SMN2ALDH1A1LMNA
SCHEMBL8369354 0.85 TCF4 (0.80) PLAUTCF4CTNNB1SMN1; SMN2LMNA
SCHEMBL16116951 0.84 TCF4 (1.00) PLAUTCF4CTNNB1PLATSMN1; SMN2
SCHEMBL28327806 0.83 TCF4 (0.61) PLAUTCF4CTNNB1PLATAKR1C3
SCHEMBL11579834 0.83 TCF4 (0.65) PLAUTCF4CTNNB1PLATSMN1; SMN2
SCHEMBL14896438 0.83 TCF4 (0.80) PLAUTCF4CTNNB1PLATSMN1; SMN2
SCHEMBL16116948 0.83 TCF4 (1.00) TCF4CTNNB1SMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831800-A4 ARYLSULFONYLAMINOBENZENE DERIVATIVES AND THE USE THEREOF AS FACTOR Xa INHIBITORS DIMENSIONAL PHARM INC (US) 1999-03-10 EP disclosed
US-5741819-A THROMBOSIS INHIBITORS; ANTIINFLAMMATORY AGENTS; NEURODEGENERATIVE DISORDERS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1998-04-21 US disclosed
EP-0831800-A1 ARYLSULFONYLAMINOBENZENE DERIVATIVES AND THE USE THEREOF AS FACTOR Xa INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1998-04-01 EP disclosed
US-5612378-A TREATING THROMBOSIS, ISCHEMIA, STROKE, RESTENOSIS OR INFLAMMATION 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1997-03-18 US disclosed
WO-1996040100-A1 ARYLSULFONYLAMINOBENZENE DERIVATIVES AND THE USE THEREOF AS FACTOR Xa INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1996-12-19 WO disclosed
WO-1996039380-A1 BIS-ARYLSULFONYLAMINOBENZAMIDE DERIVATIVES AND THE USE THEREOF AS FACTOR Xa INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1996-12-12 WO disclosed
WO-1996039132-A1 N,N-DISULFONYLATED AMINOBENZENE CARBOXYLIC ACIDS AND THE USE THEREOF AS THROMBIN INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1996-12-12 WO disclosed
US-5559150-A ANTICOAGULANT, ANTITUMOR, ANTIINFLAMMATORY 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1996-09-24 US disclosed