Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.81 |
| ▸ | MMP9 | P14780 | 17/20 | 0.81 |
| ▸ | MMP1 | P03956 | 16/20 | 0.81 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323902 | 0.89 | MMP13 (1.00) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7311162 | 0.89 | MMP9 (0.81) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7317808 | 0.89 | MMP9 (0.81) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7503956 | 0.89 | MMP9 (0.68) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7323169 | 0.89 | MMP13 (0.74) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7351229 | 0.88 | MMP9 (0.81) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7322655 | 0.88 | MMP13 (0.83) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7322979 | 0.87 | MMP13 (0.68) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7318672 | 0.87 | MMP13 (0.71) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL27533470 | 0.86 | MMP9 (0.63) | MMP13MMP9MMP1ADAM17ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |