Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313619 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 | |
| SCHEMBL30810266 | 0.82 | HPGD (0.50) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 | |
| SCHEMBL7265468 | 0.77 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 | |
| SCHEMBL7264993 | 0.76 | ALDH1A1 (0.44) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 | |
| SCHEMBL1548468 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 | |
| SCHEMBL7315586 | 0.74 | SMN1; SMN2 (0.35) | ALDH1A1GALK1MEN1KMT2APDK2 | |
| SCHEMBL7315583 | 0.74 | SMN1; SMN2 (0.35) | ALDH1A1GALK1MEN1KMT2APDK2 | |
| SCHEMBL7416031 | 0.74 | GALK1 (0.40) | ALDH1A1SERPINH1ABL1GALK1MEN1 | |
| SCHEMBL12035516 | 0.73 | ALDH1A1 (0.44) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 | |
| SCHEMBL12035850 | 0.73 | ALDH1A1 (0.44) | ALDH1A1HPGDHSD17B10SERPINH1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |
| US-4959485-A | 5-HT3 ANTAGONISTS | RORER PHARMACEUTICAL CORPORATION (US) | 1990-09-25 | — | — | US | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |