Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315583 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1TDP1TSHRKDM4E | |
| SCHEMBL9868836 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1TDP1TSHRKDM4E | |
| SCHEMBL7325722 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1TDP1TSHRKDM4E | |
| SCHEMBL7332624 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1TDP1TSHRKDM4E | |
| SCHEMBL5311964 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TDP1KDM4EMAPK1 | |
| SCHEMBL28358079 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TDP1KDM4EMAPK1 | |
| SCHEMBL7313619 | 0.74 | ALDH1A1 (0.41) | ALDH1A1TSHRGALK1MEN1LMNA | |
| SCHEMBL7313612 | 0.74 | ALDH1A1 (0.41) | ALDH1A1TSHRGALK1MEN1LMNA | |
| SCHEMBL19888383 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1TDP1KDM4EMAPK1 | |
| SCHEMBL28961190 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TDP1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959485-A | 5-HT3 ANTAGONISTS | RORER PHARMACEUTICAL CORPORATION (US) | 1990-09-25 | — | — | US | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |