SCHEMBL7313706

SCHEMBL7313706

CCCc1ccc(OP(=O)(O)CN[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)NCCC(=O)O)cc1

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MMEL1 Q495T6 1/20 0.50
SRC P12931 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.45
MME P08473 1/20 0.41
ECE1 P42892 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7318912 0.92 MMEL1 (0.51) MMEL1SRCL3MBTL1
SCHEMBL7310423 0.91 MMEL1 (0.57) MMEL1MME
SCHEMBL7316584 0.91 MMEL1 (0.57) MMEL1MME
SCHEMBL7317532 0.91 MMEL1 (0.52) MMEL1SRC
SCHEMBL7322138 0.91 MMEL1 (0.52) MMEL1SRC
SCHEMBL7341079 0.89 MMEL1 (0.50) MMEL1SRC
SCHEMBL7309963 0.89 MMEL1 (0.52) MMEL1SRC
SCHEMBL7309907 0.87 MMEL1 (0.48) MMEL1SRC
SCHEMBL7313027 0.87 MMEL1 (0.52) MMEL1
SCHEMBL7319234 0.86 MMEL1 (0.49) MMEL1SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0592367-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1994-04-13 EP disclosed
US-5294632-A Diuretics and vasorelaxants CIBA-GEIGY CORPORATION (US) 1994-03-15 US disclosed
EP-0511940-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1992-11-04 EP disclosed
US-5155100-A Treating cardiovascular disorders in mammals CIBA-GEIGY CORPORATION (US) 1992-10-13 US disclosed